Lymphopenia in dogs is defined as a reduced level of circulating lymphocytes in peripheral blood < 1 - 4.8 x 109/L.
Lymphocytes are responsible for control of infections, regulation of neoplastic conditions and autoimmunity states and numerous disorders can cause reduced levels of these leucocytes in peripheral blood.
As a consequent of lymphopenia, dogs may be more susceptibile to bacterial, fungal and viral infections, prolonged allograft survival, cutaneous anergy and abnormal antibody responses to T-dependent antigens.
Lymphopenia can be observed in dogs with:
- Immune-mediated hemolytic anemia
- Waldenström's macroglobulinemia
- Exocrine pancreatic insufficiency
- Leukocyte adhesion deficiency
- Intestinal lymphangiectasia
- Lymphocytic-plasmacytic enteritis
- Immune-mediated neutropenia
Determination of the underlying cause(s) of this symptom and its diagnosis is essential before initiating treatment.
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