Lysosomal storage disease

From Dog

Lysosomal storage diseases are a relatively uncommon genetic disease in dogs.

below are listed some of the more common disease reported in dogs[1].

Disease Deficiency type Breeds
Alpha-mannosidosis Unknown in dogs
Ceroid lipofuscinosis (Batten disease) - Cathepsin D deficiency - neuronal lipid accumulation American Bulldog, American Pit Bull Terrier, American Staffordshire Terrier, Australian Cattle Dog
CLN5 Border Collie, Chihuahua, Cocker Spaniel, Corgi
CLN2 Dachshund, Dalmatian
CLN8 English Setter, Golden Retriever, Labrador Retriever, Miniature Schnauzer, Polish Lowland Sheepdog, Blue Heeler, Saluki, Tibetan Terrier
Fucosidosis α-L-fucosidase English Springer Spaniel
Galactosialidosis Protective protein/Cathepsin A Schipperke
Gangliosidosis GM1 Type I - β-galactoside Beagle-cross, English Springer Spaniel
Type II - β-galactoside Alaskan Husky, Portuguese Water Dog, Shiba Dog
Gangliosidosis GM2 Type I - Hexosaminidase A German Short-haired Pointer, Japanese Spaniel
Hexosaminidase A and B Golden Retriever
Glucocerebrosidosis (Gaucher's disease) β-D-Glucocerebrosidase Sydney Silky Terrier
Globoid cell leukodystrophy neuronal galactocerebrosidase deficiency
Glycogenosis Type Ia (von Gierke disease) - glucose-6-phosphatase deficiency Maltese
Type II (Pompe's disease) - α-glucosidase deficiency Lapland Dog
Type IIIa - glycogen debranching enzyme Curly-coated Retriever
Mucopolysaccharidosis Type I - α-L-iduronidase Plott Hound, Rottweiler
Type II - Iduronate-2-sulfatase Labrador Retriever, Miniature Pinscher
Type III A - Heparan-N-sulfatase (Type A) Dachshund, Huntaway
Type III B - N-acetyl-α-D-glucosaminidase (Type B) Schipperke
Niemann-Pick disease Type A - Sphingomyelinase Miniature Poodle
Type C - NPC1 mutation Boxer

References

  1. Dewey, CW (2008) A practical guide to canine and feline neurology. 2nd edition. Iowa State University Press, Iowa. pp:117-119