MOPP lymphoma protocol
From Dog
The MOPP lymphoma protocol is a chemotherapy regimen used for treatment of lymphoma in dogs[1].
MOPP, which is an acronym of mustargen (mechlorethamine), oncovin (vincristine), procarbazine and prednisone, is used as an alternative to the Madison Wisconsin lymphoma protocol.
| Day | Drug used |
| 0 | Mechlorethamine 3.0 mg/m2 |
| Vincristine 0.75 mg/m2 | |
| Procarbazine 50 mg/m2 PO SID x 14 days | |
| Prednisolone 30 mg/m2 PO SID × 14 days | |
| 7 | Mechlorethamine 3.0 mg/m2 |
| Vincristine 0.75 mg/m2 |
Repeat above course on day 28.
Hematology is usually performed on days 0, 7, 28 etc.
References
- ↑ Spugnini EP et al (2011) Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors. J Transl Med 9:221
