Mechlorethamine

From Dog

Mechlorethamine (chlormethine, mustine, HN2) is a nitrogen mustard alkylating chemotherapy agent used for treatment of cancer in dogs[1]. It was one of the original nitrogen mustard agents used in human clinical trials in the late 1940s.

This drug is used as part of the MOPP protocol for therapy against canine lymphoma.

It is also used in combination with vincristine, procarbazine and prednisone as a rescue protocol for lymphoma[2][3].

Primary side-effects with this drug is vasculitis, gastroenteritis, leucopenia and thrombocytopenia[4].

Recommended dose rate in dogs is 3 mg/m2 given IV.

References

  1. Northrup NC et al (2009) Mechlorethamine, procarbazine and prednisone for the treatment of resistant lymphoma in dogs. Vet Comp Oncol 7(1):38-44
  2. Fahey CE et al (2011) Evaluation of the University of Florida lomustine, vincristine, procarbazine, and prednisone chemotherapy protocol for the treatment of relapsed lymphoma in dogs: 33 cases (2003-2009). J Am Vet Med Assoc 239(2):209-215
  3. Northrup NC et al (2009) Mechlorethamine, procarbazine and prednisone for the treatment of resistant lymphoma in dogs. Vet Comp Oncol 7(1):38-44
  4. Abb J et al (1977) Hematologic and immunologic studies in dogs given nitrogen mustard (hn3). Blut 35(1):51-56