Megestrol acetate is a steroidal progestin and progesterone derivativewith predominantly progestational and antigonadotropic effects.
It is used in dogs for:
- Appetite stimulation
- False pregnancy
- Estrus suppression
- Infertility in bitches with short inter-estrous periods
A leading side-effect of this drug is development of cystic endometrial hyperplasia and pyometra when used for protracted periods as an estrus suppressant, and a greater risk of mammary tumor development, particularly the Beagle.
Recommended dose rate in dogs is 0.5 mg/kg once daily for eight days.
- Arora N et al (2006) A model for cystic endometrial hyperplasia/pyometra complex in the bitch. Theriogenology 66(6-7):1530-1536
- Rabe T & Runnebaum B (1986) Progestins and carbohydrate metabolism. Int J Fertil 31:31-45