Melarsomine dihydrochloride

From Dog

Melarsomine dihydrochloride is an adulticidal drug used for treatment of canine heartworm disease caused by Dirofilaria immitis.

This drug has largely replaced older arsenical drugs such as thiacetarsamide, and ease of administration as a single monthly injections obviates the risks of vasculitis.

Side-effects due to all adulticidal drugs have an inherent risk of sudden death due to thromboembolism and should be used cautiously, often with pre-adulticidal use of doxycycline and prednisolone[1].

Recommended dose rate is 2.5 mg/kg given as a single intramuscular injection, repeated monthly or trimonthly as required.


  1. Kramer L et al (2011) Evaluation of lung pathology in Dirofilaria immitis-experimentally infected dogs treated with doxycycline or a combination of doxycycline and ivermectin before administration of melarsomine dihydrochloride. Vet Parasitol 176(4):357-360