From Dog

Mesalliance (mismating) is a relatively common reproductive disorder of dogs which occurs from unwanted mating between two dogs.

Although some pregnancies are allowed to continue, dog owners frequently request veterinary intervention to either terminate the pregnancy or for elective ovariohysterectomy.

Mesalliance has been treated successfully with diethylstilboestrol, although bone marrow suppression is a real-risk with use of this drug.

Other drugs include deslorelin, cabergoline, misoprostol and alfaprostol[1].


  1. Cetin Y et al (2010) Intravaginal application of misoprostol improves pregnancy termination with cabergoline and alfaprostol in dogs. Berl Munch Tierarztl Wochenschr 123(5-6):236-242