Mesna

From Dog

Mesna (sodium 2-mercaptoethane sulfonate) is an organosulfur compound which acts as an antioxidant and mucolytic.

Mesna is a pharmacologically unremarkable, physiologically largely inert and almost totally non-toxic thio compound that is rapidly eliminated renally and only slightly permeates into tissues.

IThe detoxifying action of mesna is limited to the kidneys and the efferent urinary tract. The systemic effects of the oxazaphosphorines, however, remain unaffected[1].

This drug has been used in canine chemotherapy where it is incorporated into an adjunct therapy with cyclophosphamide[2] and ifosfamide[3] to prevent hemorrhagic cystitis.

Recommended dose rate in dogs is 40% of cyclophosphamide or ifosfamide dose, given orally or parenterally every 3 hours for 24 hours.

References

  1. Brock N et al (1982) Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--III. Profile of action of sodium 2-mercaptoethane sulfonate (mesna). Eur J Cancer Clin Oncol 18(12):1377-1387
  2. Moore AS & Kitchell BE (2003) New chemotherapy agents in veterinary medicine. Vet Clin North Am Small Anim Pract 33(3):629-49
  3. Rassnick KM et al (2000) Evaluation of ifosfamide for treatment of various canine neoplasms. J Vet Intern Med 14(3):[http://www.ncbi.nlm.nih.gov/pubmed/10830540 271-276