Metformin is an oral biguanide antihyperglycemic agent for treatment of non-insulin-dependent diabetes mellitus.
In diabetic dogs, metformin primarily control blood glucose levels by inhibiting hepatic glucose production through a decrease in hepatic glycogenolysis.
- Sasaki H et al (2009) Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. Circulation 119(19):2568-2577
- Chu CA et al (2000) The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis. Metabolism 49(12):1619-1626
- Plumb DC (2005) Veterinary drug handbook. 5th ed. Ames: Iowa State University Press. pp:498-499