Metronidazole

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Metronidazole is an oral synthetic antiprotozoal and antibacterial agent recommended for anaerobic bacterial diseases.

Following oral administration, metronidazole is well absorbed, with peak plasma concentrations occurring between one and two hours after administration.

Both the parent compound and the metabolite possess in vitro bactericidal activity against most strains of anaerobic bacteria and some protozoa.

Metronidazole appears in cerebrospinal fluid, saliva, and milk in concentrations similar to those found in plasma. Bactericidal concentrations of metronidazole have also been detected in pus from hepatic abscesses.

The major route of elimination of metronidazole and its metabolites is via the urine, with fecal excretion accounting for 10% of the dose.

Metronidazole is effective against:

- Bacteroides spp
- Fusobacterium spp
- Clostridium spp
- Tritrichomonas spp
- Entamoeba histolytica