Moxifloxacin

From Dog

Moxifloxacin is a fluoroquinolone antimicrobial drug similar to enrofloxacin and acts by inhibiting DNA gyrases within bacteria.

It has a wide range of activity against Gram-positive and Gram-negative bacteria.

This drug is primarily reserved for use against resistant strains of mycobacterium[1].

This drug has been shown to have in vitro efficacy against Mycobacterium fortuitum and Mycobacterium smegmatis[2] but weak bactericidal activity against Pseudomonas aeruginosa[3].

The recommended dose rate in dogs is 5 - 10 mg/kg given once daily. Higher doses may result in phototoxicity and intravenous use may induce a histamin-release-induced QT prolongation[4].

References

  1. Malik R et al (2013) Ulcerated and nonulcerated nontuberculous cutaneous mycobacterial granulomas in cats and dogs. Vet Dermatol 24(1):146-153
  2. Govendir M et al (2011) Susceptibility of rapidly growing mycobacteria isolated from cats and dogs, to ciprofloxacin, enrofloxacin and moxifloxacin. Vet Microbiol 147(1-2):113-118
  3. Ledbetter EC et al (2007) In vitro fluoroquinolone susceptibility of Pseudomonas aeruginosa isolates from dogs with ulcerative keratitis. Am J Vet Res 68(6):638-642
  4. Patmore L et al (2000) Effects of sparfloxacin, grepafloxacin, moxifloxacin, and ciprofloxacin on cardiac action potential duration. Eur J Pharmacol 406(3):449-452