Nicergoline

From Dog

Nicergoline is an alpha-adrenergic antagonist derived from ergot and has vasodialtory effects on cerebral circulation[1][2].

Its effects on improving cognitive function in dogs with cognitive dysfunction syndrome is open to question as some studies have not shown any therapeutic benefits[3] compared with cabergoline or adrafinil[4].

Recommended dose rate in dogs is 5 μg/kg given orally once daily.

References

  1. Payen DM et al (1985) Sustained ventricular unloading action of the alpha-adrenergic antagonist nicergoline in the dog. Crit Care Med 13(8):656-660
  2. Lièvre M et al (1985) Centrally mediated cardiovascular effects of nicergoline in the dog compared to those of clonidine. Eur J Pharmacol 117(1):103-107
  3. Siwak CT et al (2000) Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs. Am J Vet Res 61(11):1410-1414
  4. Yamada S et al (1995) Effects of VA-045 on peripheral and central circulation in anesthetized dogs. Gen Pharmacol 26(6):1419-1424