Omeprazole acts on the gastric parietal cells on the luminal surface, inhibiting H+/K+ ATPase. This prevents the final step in gastric hydrochloric acid secretion, and these class of drugs are more potent than H2 antagonists such as cimetidine, famotidine or ranitidine. The long term consequences of blockage of hydrochloric acid secretion is predisposition to gastric haemorrhages, gastric polyps and gastric carcinoids.
Omeprazole has no direct antiemetic effects and produces clinical well-being through its effects on reducing symptoms associated with gastric hyerpacidity.
The recommended dose in dogs is 0.5 - 1 mg/kg once or twice daily.
- Carlsson, E (1989) A review of the effects of long-term acid inhibition in animals. Scand J gastroenterol Suppl 166:19-23