Orbifloxacin

From Dog

Orbifloxacin is a fluoroquinolone antimicrobial agent similar to enrofloxacin and exhibits bactericidal activity against numerous Gram-negative and Gram-positive bacteria.

In canine practice, orbifloxacin is indicated for the treatment of various infections, including urinary, skin, and otitis infections. It is specifically active against E. coli and Pseudomonas aeruginosa[1].

It does not appear as efficacious as enrofloxacin, ciprofloxacin or marbofloxacin against Staphylococcus pseudintermedius[2].

Recommended dose rate in dogs is 2.5 - 7.5 mg/kg given orally every 24 hours.

References

  1. Harada K et al (2012) Post-antibiotic effect of orbifloxacin against Escherichia coli and Pseudomonas aeruginosa isolates from dogs. Acta Vet Scand 54:16
  2. Awji EG et al (2012) Comparative mutant prevention concentration and mechanism of resistance to veterinary fluoroquinolones in Staphylococcus pseudintermedius. Vet Dermatol 23(4):376-380