From Dog

Osteosclerosis, the opposite of osteoporosis, is defined as hardening of bone cortices.

In canine medicine, osteosclerosis is often associated with regional bone hardening in response to arthritis, pyruvate kinase deficiency[1] and fractures such as fragmented coronoid process.


  1. Gultekin GI et al (2012) Erythrocytic pyruvate kinase mutations causing hemolytic anemia, osteosclerosis, and seconday hemochromatosis in dogs. J Vet Intern Med 26(4):935-944