Oxybutynin

From Dog

Oxybutynin is a muscarinic-receptor antagonist which acts of as a sympathomimetic drug on cholinergic nerve endings, resulting in increased smooth muscle control[1], causing increased urethral tone and ocular ciliary muscle contractions[2].

This drug is primarily used for canine incontinence, with clinically similar effects to pseudoephedrine.

References

  1. Sudoh K et al (1997) Different effect of anticholinergic agents and potassium channel openers on urinary bladder response to pelvic nerve stimulation in anaesthetized dogs. J Auton Pharmacol 17(2):91-96
  2. Choppin A & Eglen RM (2001) Pharmacological characterization of muscarinic receptors in dog isolated ciliary and urinary bladder smooth muscle. Br J Pharmacol 132(4):835-842