Oxyporus spp

From Dog

Oxyporus spp are a filamentous basidiomycetous fungus which is normally found as a commensal on rotting vegetation.

Dogs are thought to become infected from ingesting or inhaling conidial spores while foraging, through skin wounds or when eating small amphibians and reptiles.

Oxyporus are an opportunistic pathogen that causes infections characterized by progressive granulomatous lesions in the subcutaneous tissues as well as disseminated visceral infections[1].

Species which are pathogenic to dogs include:

  • Oxyporus corticola

In dogs, disseminated infections have been reported, with dogs presenting primarily with cutaneous lesions, regional lymphadenopathy and osteomyelitis[2].

Diagnosis can be ascertained by microscopic identification of the fungus or by PCR assay speciation. Lymph nodes characteristically contain PAS positive fungal elements and portions of tissue culture produce mycelial fungal growth.

Treatment has been effective with long-term azole therapy, specifically ketoconazole or itraconazole.

References

  1. Miller SA et al (2012) Isolation and sequence-based identification of Oxyporus corticola from a dog with generalized lymphadenopathy. J Vet Diagn Invest 24(1):178-181
  2. Brockus CW et al (2009) Disseminated Oxyporus corticola infection in a German shepherd dog. Med Mycol 47(8):862-868