Pamidronate is a potent injectable aminobisphosphonates, similar in action to zoledronate.
This drug is used in canine medicine for treatment of malignancy-associated hypercalcemia.
Pamidronate is an organic pyrophosphate analogue that possesses high affinity for bone hydroxyapatite crystals and induces osteoclast apoptosis. The inhibition of global osteoclastic activity decreases overall bone resorption and calcium release from the bone compartment.51-53
Following initiation of therapy with this drug, ionized calcium levels usually normalize within 4 - 10 days, and the effect lasts for about one to four weeks.
Recommended dose rate in dogs is 1.3 - 2 mg/kg given once intravenously over 20 minutes or two hours in vitamin D toxicosis.
An alternative safe dosage is 1 - 2 mg/kg given intravenously over two hours every 21 to 28 days.
- Body JJ et al (1996) Use of bisphosphonates in cancer patients. Cancer Treat Rev 22:265-287
- Rogers MJ et al (1997) Overview of bisphosphonates. Cancer 80(8):1652-1660