Pamidronate

From Dog

Pamidronate is a potent injectable aminobisphosphonates, similar in action to zoledronate.

This drug is used in canine medicine for treatment of malignancy-associated hypercalcemia.

Pamidronate is an organic pyrophosphate analogue that possesses high affinity for bone hydroxyapatite crystals and induces osteoclast apoptosis[1]. The inhibition of global osteoclastic activity decreases overall bone resorption and calcium release from the bone compartment.51-53

Following initiation of therapy with this drug, ionized calcium levels usually normalize within 4 - 10 days, and the effect lasts for about one to four weeks[2].

Recommended dose rate in dogs is 1.3 - 2 mg/kg given once intravenously over 20 minutes or two hours in vitamin D toxicosis.

An alternative safe dosage is 1 - 2 mg/kg given intravenously over two hours every 21 to 28 days.

References

  1. Body JJ et al (1996) Use of bisphosphonates in cancer patients. Cancer Treat Rev 22:265-287
  2. Rogers MJ et al (1997) Overview of bisphosphonates. Cancer 80(8):1652-1660