Paraneoplastic syndrome

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Paraneoplastic syndromes are a group of noncancerous diseases associated with internal neoplasia[2].

Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as cardiac abnormalities (e.g. ventricular tachycardia[3] due to underlying neuroendocrine disease), neuromuscular changes (e.g. paraneoplastic myasthenia gravis[4]), ocular changes (e.g. uveitis[5]), hematological changes (e.g. leukocytosis, eosinophilia, hypoglycemia, hypoalbuminemia, regenerative anemia and hypercalcemia[6]) as well as general clinical signs of weight loss, polyuria, polydipsia, diarrhea and anorexia.

A number of diseases can result in paraneoplastic syndrome, including:

Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology[17].


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