Peliosis hepatis

From Dog
Peliosis hepatis in a dog[1]

Peliosis hepatis is a rare benign vascular disorder characterised by randomly distributed multiple blood-filled cavities throughout the liver.

These tumors histologically appear as proliferative lesions within the liver often lined by prominent endothelium.

The pathogenesis of peliosis hepatis is still unclear, but is associated with high levels of vascular endothelial growth factor, which has been shown to be activated by parasitism with Bartonella henselae[2].

The animal may eventually die of a combination of hemodilutional anemia and circulatory failure[3]

This condition can also occur in association with mast cell tumor Waldenstrom macroglobulinemia, hepatocarcinoma and long-term prednisolone therapy.

Toxicity reactions with azathioprine usage has also resulted in this condition, which appears to be more common in cats.

References

  1. Uni of Pennsylvania
  2. Kitchell BE et al (2000) Peliosis hepatis in a dog infected with Bartonella henselae. J Am Vet Med Assoc 216(4):519-523
  3. Kelly WR (1993) Hyperplastic and Neoplastic Lesions of Liver and Bile Ducts. In: Jubb, Kennedy, Palmer., editors. Pathology of Domestic Animals. ed.4. Vol. 2. Academic Press; New–York. pp. 402–406