Phenylpropanolamine

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Phenylpropanolamine is a partial α1-agonist drug with a low intrinsic activity and affinity, that acts on the urethral sphincter mechanism.

This drug is primarily used as a medical treatment of canine incontinence[1] and is more effective than pseudoephedrine and with fewer side-effects[2]..

The reported success rate associated with this treatment ranges from 85% - 97% continence[3], but a decrease in urethral response associated with recurrence of incontinence can be observed after a prolonged administration of this drug[4].

Rare side-effects have been noted in dogs, including hyperexcitability and hypertension when given at high doses[5].

Recommended dose rate in dogs is 1 - 1.5 mg/kg body weight two to three times daily[6].

References

  1. Claeys S et al (2011) Clinical evaluation of a single daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. Can Vet J 52(5):501-505
  2. Byron JK et al (2007) Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs. J Vet Intern Med 21(1):47-53
  3. Burgherr T et al (2007) Efficacy, tolerance and acceptability of Incontex in the context of spayed bitches with urinary incontinence. Schweiz Arch Tierheilkd 149:307–313
  4. White RA & Pomeroy CJ (1989) Phenylpropanolamine: An alpha-adrenergic agent for the management of urinary incontinence in the bitch associated with urethral sphincter mechanism incompetence. Vet Rec 125:478–480
  5. DiBartola SP & Adams WM (1983) Urinary incontinence associated with mal-position of the urinary bladder. In: Kirk RW, editor. Current Veterinary Therapy VIII Small Animal Practice. Philadelphia: Saunders. pp:1089–1092
  6. Scott L et al (2002) Evaluation of phenylpropanol-amine in the treatment of urethral sphincter mechanism incompetence in the bitch. J Small Anim Pract 43:493–496