The polyostotic distribution of this disease appears to be caused by hemolymphatic spread of neoplastic cells.
Affected dogs usually present with signs referable to skeletal disease, mainly progressive paraparesis, regional pain, lameness, spondylarthrosis and anorexia.
Pathological fractures have also been reported in young dogs, due to overactivity normally associated with pups.
Although older dogs are often affected, it has been reported in pups at 5 months of age.
Secondary metastases to the spleen and liver are commonly reported.
Radiographs usually reveal lysis and proliferative changes within the physes of affected bones.
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