Pralidoxime

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Pralidoxime (2-PAM) is an antidote used specifically for aldicarb[1], malathion[2] and dichlorvos[3] toxicity in dogs.

This drug binds to organophosphate-inactivated acetylcholinesterase and thus is used to combat poisoning by organophosphates.

It is often used in conjunction with diazepam to ameliorate muscle fasciculation and seizures.

Recommended dose rate in dogs is 20 mg/kg given intravenously, intramuscularly or subcutaneously every 12 hours[4].

References

  1. Anastasio JD & Sharp CR (2011) Acute aldicarb toxicity in dogs: 15 cases (2001-2009). J Vet Emerg Crit Care (San Antonio) 21(3):253-260
  2. Sadeghi D & Guiti N (1970) Pralidoxime iodide (PAM) and toxogonin as antidotes in acute malathion intoxication in the dog. Isr J Med Sci 6(1):154-156
  3. Dellinger JA et al (1987) Latent dichlorvos neurotoxicity detected by vagal tone monitoring in dogs. Neurotoxicol Teratol 9(3):197-201
  4. Lemanowicz EF et al (1979) Kinetics of absorption and elimination of pralidoxime chloride in dogs. J Pharm Sci 68(2):141-145