Prekallikrein is a plasma protein that modulates the rate of activation of factors XI and factor XII in the intrinsic clotting system. In the absence of prekallikrein, factor XII is activated more slowly.
This disease is normally an asymptomatic condition, but post-operative bleeding may occur.
Prekallikrein deficiency has been reported in the Poodle. Combined prekallikrein deficiciency and factor XII deficiency has been reported in the Shar Pei, German Short-haired Pointer and Shih Tzu.
- Cheville, NF (2006) Introduction to veterinary pathology. 3rd edition. Wiley-Blackwell Publications
- Cornell University
- Lisciandro, GR et al (2000) Contact factor deficiency in a German Shorthaired Pointer without clinical evidence of coagulopathy. J Vet Intern Med 14:308–310
- Okawa T et al (2011) Prekallikrein deficiency in a dog. J Vet Med Sci 73(1):107-111
- Chinn DR et al (1986) Prekallikrein deficiency in a dog. J Am Vet Med Assoc 188(1):69-71
- Otto, CM et al (1991) Factor XII and partial prekallikrein deficiencies in a dog with recurrent gastrointestinal hemorrhage. J Am Vet Med Assoc 198:129–131
- Merck Veterinary Manual