From Dog

Prochlorperazine is a mixed α1/α2 and dopaminergic D2 receptor antagonist with antiemetic and analgesic properties[1].

This is drug is a pre-anesthetic sedative agent which is also used for motion sickness.

Few side-effects have been reported in dogs when given at recommended doses[2].

Recommended dose rate in dogs is 0.1 mg/kg IM given every 6 - 12 hours.


  1. Avram MJ et al (2007) Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs. Drug Metab Dispos 35(2):262-267
  2. Niemegeers CJ (1982) Antiemetic specificity of dopamine antagonists. Psychopharmacology (Berl) 78(3):210-213