Progressive retinal atrophy - rcd 1a
Progressive retinal atrophy (PRA) is a well-recognized autosomal-recessive genetic disease characterised by degeneration of the photoreceptor cells in the retina of Sloughi dogs, eventually leading to complete blindness.
The disease in this breed is caused by a frame-shift mutation in the PDE6B gene.
Most PRA cases in the Sloughi are clinically indistinguishable from other forms of PRA.
In Sloughi dogs, the disease usually has a late onset with first noticeable signs of vision loss usually evident at 2 to 3 years of age.
A species DNA test is available for testing for this condition.
There is no known treatment for this condition and severely affected individual dogs often remain blind.
- Dekomien G et al (2000) Generalized progressive retinal atrophy of Sloughi dogs is due to an 8-bp insertion in exon 21 of the PDE6B gene. Cytogenet Cell Genet 90(3-4):261-267