Propranolol

From Dog

Propranolol (Propanolol) is a sympatholytic non-selective β-blocker similar in properties to atenolol, but its effect seems less consistent[1].

It has gained popularity in human medicine for treatment in post-traumatic stress disorders and may eventuality be used in canine medicine for a similar purpose.

It is primarily used in canine medicine for regulation of various arrhythmias such as atrial fibrillation[2] and pseudoephedrine toxicosis.

Propranolol's pharmacokinetic effects are counteracted by the phosphodiesterase inhibitor aminophylline[3].

The recommended dose rate is 0.3 to 1.0 mg/kg one to three times daily.

References

  1. Nolan ER et al (2008) Effect of autonomic blockade on ventricular repolarization shortening: response to behavioral stimulus in paced dogs. Auton Neurosci 140(1-2):66-71
  2. Moers AM et al (2012) Pharmacological prevention and termination of focal atrial fibrillation. Europace 14(3):426-430
  3. Hirota K et al (2001) A comparison of the relaxant effects of olprinone and aminophylline on methacholine-induced bronchoconstriction in dogs. Anesth Analg 93(1):230-233