Prostatic atrophy is a rare disease of the prostate of male dogs.
Androgen is required for the survival of epithelial cells and to maintain growth-quiescent fibromuscular cells, while basal cell proliferation is androgen independent. Castration, which eliminates the androgen source results in reduction of epithelial components of the gland.
Prostatic atrophy appears to occur as a result of gradual cellular apoptosis, as observed in experimentally induced atrophy due to botox injections.
- Chuang YC et al (2006) Intraprostatic injection of botulinum toxin type-A relieves bladder outlet obstruction in human and induces prostate apoptosis in dogs. BMC Urol 6:12
- Silva J et al (2009) Mechanisms of prostate atrophy after glandular botulinum neurotoxin type a injection: an experimental study in the rat. Eur Urol 56(1):134-140
- Shidaifat F et al (2007) Effect of castration on extracellular matrix remodeling and angiogenesis of the prostate gland. Endocr J 54(4):521-529
- Al-Omari R et al (2005) Castration induced changes in dog prostate gland associated with diminished activin and activin receptor expression. Life Sci 77(22):2752-2759
- Juodziukyniene N et al(2010) Effect of age, hyperplasia and atrophy on collagen parameters in dog prostates. Pol J Vet Sci 13(3):479-485
- O'Shea JD (1962) Studies on the canine prostate gland. 1 factors influencing its size and weight. J Comp Pathol 72:321-331