Prostatic atrophy

From Dog
Comparative sizes of prostate following botox injections in the dog model[1]

Prostatic atrophy is a rare disease of the prostate of male dogs.

Prostatic atrophy occurs due to a reduction in androgen concentrations and sympathetic drive[2], often a result of castration[3].

Androgen is required for the survival of epithelial cells and to maintain growth-quiescent fibromuscular cells, while basal cell proliferation is androgen independent[4]. Castration, which eliminates the androgen source results in reduction of epithelial components of the gland[5].

Prostatic atrophy appears to occur as a result of gradual cellular apoptosis, as observed in experimentally induced atrophy due to botox injections.

Dogs with Sertoli cell tumor develop atrophy, but there is also a risk of development of squamous metaplasia[6].


References

  1. Chuang YC et al (2006) Intraprostatic injection of botulinum toxin type-A relieves bladder outlet obstruction in human and induces prostate apoptosis in dogs. BMC Urol 6:12
  2. Silva J et al (2009) Mechanisms of prostate atrophy after glandular botulinum neurotoxin type a injection: an experimental study in the rat. Eur Urol 56(1):134-140
  3. Shidaifat F et al (2007) Effect of castration on extracellular matrix remodeling and angiogenesis of the prostate gland. Endocr J 54(4):521-529
  4. Al-Omari R et al (2005) Castration induced changes in dog prostate gland associated with diminished activin and activin receptor expression. Life Sci 77(22):2752-2759
  5. Juodziukyniene N et al(2010) Effect of age, hyperplasia and atrophy on collagen parameters in dog prostates. Pol J Vet Sci 13(3):479-485
  6. O'Shea JD (1962) Studies on the canine prostate gland. 1 factors influencing its size and weight. J Comp Pathol 72:321-331