Prostatic squamous metaplasia

From Dog
Fine needle aspirate from a canine prostate with squamous metaplasia. The smear contains numerous well-differentiated squamous cells with varying degrees of keratinisation. Most squamous cells exhibit a low nucleus: cytoplasm ratio and contain abundant pale to basophilic cytoplasm. Mild suppurative inflammation and blood contamination are also present[1]

Prostatic squamous metaplasia is a rare prostate disease of male dogs.

The most dramatic forms of squamous metaplasia occur with exposure to estrogens or in feminizing syndrome[2].

Diagnosis is based on histological analysis of prostatic biopsies[3] done by exploratory laparotomy or ultrasound guided percutaneous sampling.

A differentail diagnosis would include prostatic atrophy. prostatitis, prostatic hyperplasia and prostatic adenocarcinoma[4].

There is no known treatment for this disease other than correction of underlying hormonal disorders.


  1. Ireland Veterinary Journal
  2. O'Shea JD (1963) Squamous metaplasia of the canine prostate gland. Res Vet Sci 4:431-434
  3. Powe JR et al (2004) Evaluation of the cytologic diagnosis of canine prostatic disorders. Vet Clin Pathol 33(3):150-154
  4. Orgad U et al (1984) Histochemical studies of epithelial cell glycoconjugates in atrophic, metaplastic, hyperplastic, and neoplastic canine prostate. Lab Invest 50(3):294-302