Protamine zinc insulin
Promatine zinc insulin is generally considered to be long acting, with slow absorption from subcutaneous tissue.
Onset of action is around 3 - 4 hours, peaking at around 14 hours.
- Clark M et al (2012) Pharmacokinetics and pharmacodynamics of protamine zinc recombinant human insulin in healthy dogs. J Vet Pharmacol Ther 35(4):342-350
- Maggiore AD et al (2012) Efficacy of protamine zinc recombinant human insulin for controlling hyperglycemia in dogs with diabetes mellitus. J Vet Intern Med 26(1):109-115
- Davison LJ et al (2008) Anti-insulin antibodies in diabetic dogs before and after treatment with different insulin preparations. J Vet Intern Med 22(6):1317-1325