Protamine zinc insulin

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Protamine zinc insulins are an synthetic insulin used for treatment of canine diabetes mellitus.

Promatine zinc insulin is generally considered to be long acting, with slow absorption from subcutaneous tissue.

Onset of action is around 3 - 4 hours, peaking at around 14 hours[1].

Hypoglycemia[2] and anti-insulin antibodies[3] (with subsequent insulin resistance) are consistent side-effect with overdosing with this drug.


  1. Clark M et al (2012) Pharmacokinetics and pharmacodynamics of protamine zinc recombinant human insulin in healthy dogs. J Vet Pharmacol Ther 35(4):342-350
  2. Maggiore AD et al (2012) Efficacy of protamine zinc recombinant human insulin for controlling hyperglycemia in dogs with diabetes mellitus. J Vet Intern Med 26(1):109-115
  3. Davison LJ et al (2008) Anti-insulin antibodies in diabetic dogs before and after treatment with different insulin preparations. J Vet Intern Med 22(6):1317-1325