Pyridoxine (3-hydroxy-4,5-dihydroxy-methyl-2-methyl-pyridine; Vitamin B6) is an essential vitamin important for epidermal barrier function, neuronal metabolism, hemosynthesis as well as homeostasis of Na:K levels.
Pyridoxine is one form of vitamin B6, a group of water-soluble, structurally related compounds that also includes pyridoxal and pyridoxamine. These forms are about equally active and are readily interconvertible. Dogs convert pyridoxine into the enzymatically active form, pyridoxal-5-phosphate, which plays a role in a wide variety of enzyme systems, especially in the metabolic utilization and transformation of amino acids.
Pyridoxine in excess levels (> 150 mg/kg daily for 7 days) is associated with development of a reversible neuropathy in dogs characterized by weight loss, proprioceptive deficits and hindlimb ataxia.
This drug is primarily used as an adjunct treatment of anemia as well as a supportive drug in cognitive dysfunction syndrome and treatment of side-effects associated with chemotherapy (e.g. isoniazid, doxil).
Recommended daily dose for dogs is 1.0 - 2.0 mg/kg orally or subcutaneously.
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