Rifampicin

From Dog

Rifampicin is a antimicrobial drug semi-synthetically derived from Amycolatopsis rifamycinica.

This drug is primarily reserved for multi-drug treatment of canine infections with Mycobacterium spp and pyoderma associated with methicillin-resistant Staphylococcus pseudintermedius[1].

This drug has poor enteric stability and is rapidly degraded in gastric acidic environment[2].

Side-effects have been reported in multi-drug sensitivity breeds such as the Collie.

Recommended dose rate is 5 mg/kg once daily.

References

  1. Kadlec K et al (2011) Molecular basis of rifampicin resistance in methicillin-resistant Staphylococcus pseudintermedius isolates from dogs. J Antimicrob Chemother 66(6):1236-1242
  2. Wang Y et al (2012) Design and evaluation of enteric-coated tablets for rifampicin and isoniazid combinations. Pharm Dev Technol Feb 18