Round cell tumor
Mast cell tumors are the most frequent round cell tumors in dogs but can also be observed in atypical anal sac adenocarcinomas, lymphomas, melanomas, plasmacytomas, transmissible venereal tumors, histiocytomas, primitive neuroectodermal tumor, Merkel cell carcinomas and hepatic neuroendocrine tumors.
These tumors can affect the skin, kidneys, liver, bone marrow and spleen.
Histologically, these tumors appear as a monomorphous population of atypical round cells with round to oval to indented and pleomorphic nuclei, abundant eosinophilic homogenous cytoplasm, anisocytosis, anisokaryosis, atypical mitoses and associated necrotic areas.
Treatment is usually curative with wide-margin surgical excision but due to the malignant nature of these tumors, recurrence should be considered and regular monitoring is recommended.
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- Mackowiak II et al (2012) E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors. Vet J 194(3):405-11
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- Warren-Smith CM et al (2012) Lack of associations between ultrasonographic appearance of parenchymal lesions of the canine liver and histological diagnosis. J Small Anim Pract 53(3):168-173
- Shiomitsu K et al (2012) Cutaneous epitheliotropic lymphoma with dual CD3 and c-kit expression in a dog. Vet Clin Pathol 41(4):594-598