Salbutamol

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Salbutamol (Albuterol) is a β2-agonist bronchodilator drug used for asthma in humans.

This drug was used for cases of bronchitis and pulmonary interstitial fibrosis, but reduced efficacy of bronchodilation compared with humans[1] (improved expiratory airflow, but no effect on PaO2)[2] and untoward side-effects resulted in treatment regimens changing to alternative inhalants which contains corticosteroids[3].

Toxicity associated with accidental ingestion has been reported in dogs, resulting in mydriasis, paresis, ventricular tachycardia[4], hyperactivity and hypokalemia[5].

Treatment usually requires intravenous fluid administration with supplemental potassium chloride[6].

References

  1. Eng J et al (1990) Insensitivity of maximum expiratory flow to bronchodilation in normal dogs. J Appl Physiol 68(5):2006-2012
  2. Padrid PA et al (1990) Canine chronic bronchitis. A pathophysiologic evaluation of 18 cases. J Vet Intern Med 4(3):172-180
  3. Padrid P (2006) Use of inhaled medications to treat respiratory diseases in dogs and cats. J Am Anim Hosp Assoc 42(2):165-169
  4. Matos J et al (2012) Myocardial damage and paroxysmal ventricular tachycardia in a dog after Albuterol intoxication. Schweiz Arch Tierheilkd 154(7):302-305
  5. Mackenzie SD et al (2012) Oral thermal injury associated with puncture of a salbutamol metered-dose inhaler in a dog. J Vet Emerg Crit Care (San Antonio) 22(4):494-497
  6. McCown JL et al (2008) Suspected albuterol toxicosis in a dog. J Am Vet Med Assoc 232(8):1168-1171