Salivary gland adenocarcinoma
These tumors usually develop within the salivary gland, usually the mandibular, parotid and zygomatic gland.
They are metastatic in nature, commonly involving regional lymph nodes, regional bone, with hematopoietic dissemination to the lungs.
Variant forms have been reported, such as salivary gland basal cell adenocarcinoma.
Older dogs are usually affected and clinical signs include varying amounts of oral pain, dysphagia, painful swelling, often in the submandibular region, halitosis and exophthalmos. Less common signs include sudden onset blindness due to ocular metastases.
Diagnosis requires histological analysis of biopsy material, usually by fine needle aspiration. Clinical staging of tumors is a good indicator of survival time.
Excisional sialoadenectomy with wide-margins is usually curative, but a rostral mandibulectomy or total hemimandibulectomy may be required with aggressive metastatic cases. Chemotherapy is indicated in most cases, usually doxorubicin, but post-operative orthovoltage radiation therapy has also be trialled.
Prognosis is guarded, but survival times of 1 - 2 years have been reported.
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