Sebaceous carcinoma (epitheliomatous sebaceous carcinoma) are malignant neoplasms of the sweat glands of canine skin.
These lobulated wart-like exophytic skin tumors typically appear associated with sweat glands and are commonly found on the head and neck but also occasionally in the intedigital skin of the limbs.
Definitive diagnosis requires histological examination of biopsied skin. Immunohistochemical studies of these tumors reveals a signifant loss or reduction of β-catenin membrane labelling and estrogen and progesterone receptors, allowing easier differentation from other benign epithelial tumors.
Rare metastases to the lung and CNS have been reported.
Surgical excision, using wide margins is usually curative in most cases.
The prognosis with metastatic cases is considered poor, although adjunct radiation therapy may be considered following histological confirmation and surgical extirpation.
- Vet Surgery Central
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