Seminoma

From Dog
Surgical appearance of a Sertoli cell tumor with a seminoma located to the right[1]

Seminoma are a rare neoplastic testicular disease of the dog.

Primary testicular tumors, such as seminoma, are the most common causes of cancer in male dogs[2], and in humans, seminoma are part of the testicular dysgenesis syndrome[3].

Seminomas in the dog have a relatively high malignancy and high occurrence in older dogs[4], and multiple malignant metastases have been reported[5].

Unlike seminomas in humans, seminomas in animals are not typically sub-classified as classical or spermatocytic types[6] and more closely resemble human spermatocytic seminomas.

Because of their involvement of the testis, and a relationship with cryptorchidism in hermaphroditism, a differential diagnosis would include Sertoli cell tumor[7].

Concurrent prostate diseases should also be excluded prior to initiation of any remedial therapy.

Most seminomas, if treated early with elective castration, have a high survival rate.

References

  1. Herndon AM et al (2012) Testicular neoplasia in the retained testicles of an intersex male dog. J Am Anim Hosp Assoc 48(2):118-124
  2. Yu CH et al (2009) Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors. J Vet Sci 10(1):1-7
  3. Grieco V et al (2008) Evidence of testicular dysgenesis syndrome in the dog. Theriogenology 70(1):53-60
  4. Kim JH et al (2010) Canine classical seminoma: a specific malignant type with human classifications is highly correlated with tumor angiogenesis. BMC Cancer 10:243
  5. Lucas X et al (2012) Unusual systemic metastases of malignant seminoma in a dog. Reprod Domest Anim 47(4):e59-61
  6. Bush JM et al (2011) Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours. Int J Androl 34(4/2):e288-95
  7. Saegusa Y et al (2011) Spermatocytic seminoma with neuroectodermal differentiation and sertoli cell tumor in a dog. Vet Pathol 48(5):1024-1028