From Dog

Serotonin (5-hydroxytryptamine) is a neurotransmitter that regulates many neuronal activities including the gut, platelets and brain.

Altered serotonin levels contribute to vomiting[1], aggression[2], stress-induced incontinence[3] and obsessive compulsive disorders[4].

Serotonin levels can be modulated exogenously with serotonin uptake inhibitors such as fluoxetine.


  1. Zacuto AC et al (2012) The influence of esomeprazole and cisapride on gastroesophageal reflux during anesthesia in dogs. J Vet Intern Med 26(3):518-525
  2. Rosado B et al (2010) Serotonin transporter activity in platelets and canine aggression. Vet J 186(1):104-105
  3. Andrews MD et al (2011) Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. Bioorg Med Chem Lett 21(9):2715-2720
  4. Vermeire S et al (2012) Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder. Psychiatry Res 201(1):78-87