Serotonin
From Dog
Serotonin (5-hydroxytryptamine) is a neurotransmitter that regulates many neuronal activities including the gut, platelets and brain.
Altered serotonin levels contribute to vomiting[1], aggression[2], stress-induced incontinence[3] and obsessive compulsive disorders[4].
Serotonin levels can be modulated exogenously with serotonin uptake inhibitors such as fluoxetine.
References
- ↑ Zacuto AC et al (2012) The influence of esomeprazole and cisapride on gastroesophageal reflux during anesthesia in dogs. J Vet Intern Med 26(3):518-525
- ↑ Rosado B et al (2010) Serotonin transporter activity in platelets and canine aggression. Vet J 186(1):104-105
- ↑ Andrews MD et al (2011) Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. Bioorg Med Chem Lett 21(9):2715-2720
- ↑ Vermeire S et al (2012) Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder. Psychiatry Res 201(1):78-87
