Sideroblastic anemia is a canine disease characterized by bone marrow production of sideroblasts rather than healthy erythrocytes.
Sideroblasts are formed by the irregular accumulation of iron in mitochondria.
There are two forms of sideroblastic anemia, congenital sideroblastic anemia and acquired sideroblastic anemia. Congenital sideroblastic anemia has been reported in as an X-linged genetic disease in humans, but not dogs.
Blood tests usually reveal a moderate to severe nonregenerative hypochromic anemia and the presence of large iron deposits in erythroid cells.
A definitive diagnosis usually requires bone marrow biopsy and histological evidence of dysplastic erythroid cell lines in tissue samples.
Treatment usually requires addressing underlying inflammatory disease and use of drugs such as iron folate, nandrolone and dietary supplements.
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