From Dog

Silibin (silybin; silymarin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds containing mixture of flavonolignans.

This cytoprotective agents is sometimes used in combination with S-Adenosylmethionine as a more potent antioxidant in use with chemotherapy agents such as lomustine[1].

Silybin has also shown efficacy at improving clearance of Giardia spp infections when used as a supplement in conjunction with metronidazole[2].

This compound has reported hepatoprotective effects against various forms of mycotoxicosis[3].

Recommended dose rates in dogs is 50 mg/kg given as two or three separate doses every 8 - 24 hours.


  1. Skorupski KA et al (2011) Prospective randomized clinical trial assessing the efficacy of Denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs. J Vet Intern Med 25(4):838-845
  2. Chon SK & Kim NS (2005) Evaluation of silymarin in the treatment on asymptomatic Giardia infections in dogs. Parasitol Res 97(6):445-451
  3. Vogel G et al (1984) Protection by silibinin against Amanita phalloides intoxication in beagles. Toxicol Appl Pharmacol 73(3):355-362