Spironolactone

From Dog

Spironolactone is a potassium-sparing diuretic used in the treatment of hypertension, mitral valve endocardiosis[1], atrial fibrillation[2] and ascites due to chronic hepatitis[3] and congestive heart failure[4].

Spironolactone is also used to treat potassium deficiency and hyperaldosteronism.

Recommended dose rate in dogs is 2 mg/kg orally once daily[5].

References

  1. Kittleson MD & Bonagura JD (2010) Re: Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease. J Vet Intern Med 24(6):1245-1246
  2. Zhao J et al (2010) Effects of spironolactone on atrial structural remodelling in a canine model of atrial fibrillation produced by prolonged atrial pacing. Br J Pharmacol 159(8):1584-1594
  3. Raffan E et al (2009) Ascites is a negative prognostic indicator in chronic hepatitis in dogs. J Vet Intern Med 23(1):63-66
  4. de Madron E et al (2011) Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases. Can Vet J 52(11):1219-1225
  5. Guyonnet J et al (2010) A preclinical pharmacokinetic and pharmacodynamic approach to determine a dose of spironolactone for treatment of congestive heart failure in dog. J Vet Pharmacol Ther 33(3):260-267