This disease is caused by a missense mutation that produces platelets with abnormal fibrinogen receptor exposure and impaired dense granule release, and results in bleeding tendencies primarily of mucosal surfaces.
Acquired thrombocytopathia has also been reported in dogs due to Angiostrongylus vasorum, hypergammaglobulinemia associated with multiple myeloma and B-cell lymphoma as well as administration of some colloid solutions, non-steroidal anti-inflammatory drugs and cephalosporins.
Clinical signs are usually absent although buccal bleeding and hematochezia may be evident.
Diagnosis is usually with coagulation screening assays and specialized platelet function testing.
In severely affected patients, intravenous therapy with cryoprecipitates or fresh frozen plasma may be required.
- Catalfamo JL & Dodds WJ (1988) Hereditary canine thrombopathia. Vet Clin North Am Small Anim Pract 18(1):273-274
- Johnstone IB & Lotz F (1979) An inherited platelet function defect in basset hounds. Can Vet J 20:211–215
- Brooks M & Catalfamo J (1993) Buccal mucosa bleeding time is prolonged in canine models of primary hemostatic disorders. Thromb Haemost 70(5):777-780