Sulfasalazine

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Sulfasalazine (sulphonamide salicylazosulphapyridine) is an anti-inflammatory and antimicrobial drug indicated primarily for treatment of irritable bowel disease in dogs[1].

This drug is often a first choice drug for dogs with symptoms of gastroenteritis[2] or diarrhea[3].

In Boxer dogs with ulcerative colitis, this drug is frequently used in combination with prednisone, azathioprine and metronidazole[4].

Suflasalazine is also used for treatment of canine pemphigus, given in combination with prednisolone and cyclophosphamide[5].

Side-effects are rare, but induction of keratoconjunctivitis sicca has been reported. The lacrimotoxic effect of sulphasalazine is permanent in many cases and it is recommended that dogs on this drug should be monitored for tear secretion at regular intervals[6].

Recommended dose rate is 20 mg/kg given orally once daily.

References

  1. Craven M et al (2004) Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002). J Small Anim Pract 45(7):336-342
  2. Lewis DC (1995) Successful treatment of regional enteritis in a dog. J Am Anim Hosp Assoc 31(2):170-173
  3. German AJ et al (2010) First-choice therapy for dogs presenting with diarrhoea in clinical practice. Vet Rec 167(21):810-814
  4. Hostutler RA et al (2004) Antibiotic-responsive histiocytic ulcerative colitis in 9 dogs. J Vet Intern Med 18(4):499-504
  5. Rosenkrantz WS (2004) Pemphigus: current therapy. Vet Dermatol 15(2):90-98
  6. Sansom J et al (1985) Keratoconjunctivitis sicca in the dog associated with the administration of salicylazosulphapyridine (sulphasalazine). Vet Rec 116(15):391-393