Tacrolimus is a macrolide lactone formed from the fermentation of Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) production by T-cells.
It is usually available as a 1.0% ointment to be applied topically twice daily.
- Kino, T et al (1987) FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J Antibiot (Tokyo) 40(9): 1249–1255
- Balicki I (2012) Clinical study on the application of tacrolimus and DMSO in the treatment of chronic superficial keratitis in dogs. Pol J Vet Sci 15(4):667-676