Terbinafine

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Terbinafine is a synthetic allylamine antifungal commonly used in treatment of Microsporum spp and Malassezia spp infections in dogs[1].

Terbinafine inhibits ergosterol synthesis in fungal cell walls, resulting in ion leakage and cell death.

Although less efficacious than other antifungal drugs such as amphotericin B, ketoconazole, itraconazole or fluconazole, fewer side effects are reported in this species.

It has been reportedly superior to azole drugs in truncal cutaneous pythiosis[2] and intestinal Cryptococcus spp infections[3].

Recommended dose rate is 10 - 40 mg/kg every 24 hours orally for 4 weeks.

References

  1. Berger DJ et al (2012) Comparison of once-daily versus twice-weekly terbinafine administration for the treatment of canine Malassezia dermatitis - a pilot study. Vet Dermatol 23(5):418-e79
  2. Thieman KM et al (2011) Diagnosis and treatment of truncal cutaneous pythiosis in a dog. J Am Vet Med Assoc 239(9):1232-1235
  3. Olsen GL et al (2012) Use of terbinafine in the treatment protocol of intestinal Cryptococcus neoformans in a dog. J Am Anim Hosp Assoc 48(3):216-220