Toceranib is a synthetic protein kinase inhibitor drug, thought to act through inhibition of the kit tyrosine kinase, though it may also have an anti-angiogenic effects.
Side effects of toceranib use include diarrhea, anorexia, lameness and melena.
Recommended dose in dogs is 2.8 mg/kg daily.
- London CA et al (2009) Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision. Clin Can Res 15(11):3856-3865
- Mitchell L et al (2012) Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer. J Vet Intern Med 26(2):355-362