Tolfedine

From Dog

Tolfedine (tolfenamic acid) is a nonsteroidal anti-inflammatory drug similar in action to meloxicam and carprofen.

It is clinically indicated as a post-operative analgesic[1], for acute osteoarthritis and myocarditis as well as an adjunct for palliative care in cases of osteosarcoma, mammary carcinoma and melanoma.

It exerts its effects through cox-2 inhibition but also induced apoptosis in neoplastic cells[2].

Because one of the most common side-effects are vomiting and diarrhea, it is contraindicated for treatment of canine parvovirus.

Recommended dose in dogs is 4 mg/kg as a single injection, or at the same dosage orally for no more than 2 to 4 more days.

References

  1. Grandemange E et al (2007) Field evaluation of the efficacy of tolfenamic acid administered in one single preoperative injection for the prevention of postoperative pain in the dog. J Vet Pharmacol Ther 30(6):503-507
  2. Wilson H et al (2012) Effect of tolfenamic acid on canine cancer cell proliferation, specificity protein (sp) transcription factors, and sp-regulated proteins in canine osteosarcoma, mammary carcinoma, and melanoma cells. J Vet Intern Med 26(4):977-986