Toltrazuril

From Dog

Toltrazuril is a coccidiostat similar in action to amprolium.

It is commonly formulated in combination with emodepside (Procox) for use as an oral suspension against intestinal roundworms and protozoa[1].

It has proven efficacy against Eimeria spp and Cystoisospora spp[2].

Although it has a wide range of antiparasitic efficacy, it does not appear effective against Hepatozoon canis[3], even when used with imidocarb dipropionate[4].

Recommended dose rate is 10 - 30 mg/kg given orally.

References

  1. Petry G et al (2011) Efficacy of Procox® oral suspension for dogs (0.1% emodepside and 2% toltrazuril) against experimental nematode (Toxocara cati and Ancylostoma tubaeforme) infections in cats. Parasitol Res 109(1):S37-S43
  2. Daugschies A et al (2000) Toltrazuril treatment of cystoisosporosis in dogs under experimental and field conditions. Parasitol Res 86(10):797-799
  3. Pasa S et al (2011) Failure of combination therapy with imidocarb dipropionate and toltrazuril to clear Hepatozoon canis infection in dogs. Parasitol Res 109(3):919-926
  4. Macintire DK et al (1997) Hepatozoonosis in dogs: 22 cases (1989-1994). J Am Vet Med Assoc 210(7):916-922