Yohimbine

From Dog

Yohimbine is produced as an extract from Pausinystalia yohimbe and other flora and is a respiratory stimulant used to improve recovery from general anesthesia[1].

It also induces colonic peristalsis[2], and is therapeutic against mild constipation, acting antagonistically against the diuretic effect of medetomidine[3], and the antidiarrheal drugs loperamide and diphenoxylate.

Recommended dose rate is 100 - 400 μg/kg given intravenously as required[4].

References

  1. Nicholson A & Watson A (2001) Survey on small animal anaesthesia. Aust Vet J 79(9):613-619
  2. Kikuchi D et al (2013) Role of the intraluminal contents and the continuity of intrinsic neurons in intracolonic capsaicin-induced contraction and defecation in dogs. Surg Today Jan 30
  3. Talukder MH et al (2009) Antagonistic effects of atipamezole and yohimbine on medetomidine-induced diuresis in healthy dogs. Can J Vet Res 73(4):260-270
  4. Ambrisko TD & Hikasa Y (2003) The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs. Can J Vet Res 67(1):64-67