Zoledronate

From Dog

Zoledronate is a potent injectable aminobisphosphonates, similar in action to pamidronate.

This drug is used in canine medicine for treatment of malignancy-associated hypercalcemia.

Zoledronate is an organic pyrophosphate analogue that possesses high affinity for bone hydroxyapatite crystals and induces osteoclast apoptosis[1]. The inhibition of global osteoclastic activity decreases overall bone resorption and calcium release from the bone compartment.51-53

Following initiation of therapy with this drug, ionized calcium levels usually normalize within 4 - 10 days, and the effect lasts for about one to four weeks[2].

This drug has been effective at significantly increasing the activity of doxorubicin or vincristine against malignant histiocytosis[3].

Recommended dose rate in dogs is 0.1 - 0.2 mg/kg once daily.

References

  1. Body JJ et al (1996) Use of bisphosphonates in cancer patients. Cancer Treat Rev 22:265-287
  2. Rogers MJ et al (1997) Overview of bisphosphonates. Cancer 80(8):1652-1660
  3. Hafeman SD et al (2012) Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. Vet Comp Oncol 10(1):44-56