Zoledronate is a potent injectable aminobisphosphonates, similar in action to pamidronate.
This drug is used in canine medicine for treatment of malignancy-associated hypercalcemia.
Zoledronate is an organic pyrophosphate analogue that possesses high affinity for bone hydroxyapatite crystals and induces osteoclast apoptosis. The inhibition of global osteoclastic activity decreases overall bone resorption and calcium release from the bone compartment.51-53
Following initiation of therapy with this drug, ionized calcium levels usually normalize within 4 - 10 days, and the effect lasts for about one to four weeks.
Recommended dose rate in dogs is 0.1 - 0.2 mg/kg once daily.
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